"Alzheimer's Alters Circadian Clocks, Hinders Brain's Plaque-Clearing Cells"

A recent mouse study reveals that Alzheimers disease disrupts the bodys Circadian rhythm by reprogramming genes in specialized cells, impairing the brains ability to clear amyloid plaques.

• The study highlights how Alzheimers disease alters the function of microglia, the brains immune cells, crucial for clearing toxic amyloid proteins linked to neuron degeneration.
• Researchers found that changes in gene expression related to the Circadian rhythm can significantly hinder the brains plaque-clearing processes in aging mice.
• The findings underline a potential connection between sleep disturbances caused by Alzheimers disease and the impaired ability of microglia to remove harmful amyloid proteins from the brain.