"Unlocking Memory: How NMDA Receptors Control Neuron Activity"

New research reveals how NMDA receptors regulate neuron activity by controlling ion flow, impacting learning and memory, with implications for treating neurodegenerative disease.

• Scientists used cryo-electron microscopy to visualize NMDA receptors, discovering how the neurosteroid 24S-HC keeps these ion channels fully open for optimal calcium and sodium influx.
• The study showed that when NMDA receptors are fully open, calcium and sodium ions flood into the neuron, enhancing synaptic activity critical for learning and memory.
• In contrast, a synthetic compound partially closes NMDA receptors, restricting calcium ion entry and potentially offering a therapeutic approach for conditions related to neurodegenerative disease.